微生物与感染
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JOURNAL OF MICROBES AND INFECTIONS  2015, Vol. 10 Issue (6): 374-380    DOI:
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A review on the animal models of hepatitis B virus infection
REN Rong-Rong1, REN Xiao-Nan1, LI Shun1, LIU Dan-Hui2, ZHOU Xiao-Hui1
1. Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China; 2. Wenzhou Medical University, Wenzhou 325035, China

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Abstract  Hepatitis B virus (HBV) infection is a major health problem in the world, especially in China. Animal model is an important tool for studying HBV biological characteristics, pathogenesis of infection, virus-host interplay, screening of novel therapeutic targets and so on. In recent years, the development of various animal models accelerates HBV-related researches, however, all the existing models have their own disadvantages. Lacking of economical and applicable animal models that could imitate the natural course of human infection has seriously restricted the further study of HBV. This paper summarizes the current HBV animal models, which could provide the help for generation of ideal animal models.

Key wordsHepatitis B virus      Animal model      Liver     
Received: 02 August 2015      Published: 25 December 2015
Corresponding Authors: ZHOU Xiao-Hui   
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REN Rong-Rong1
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LI Shun1
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ZHOU Xiao-Hui1
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REN Rong-Rong1,REN Xiao-Nan1,LI Shun1等. A review on the animal models of hepatitis B virus infection[J]. JOURNAL OF MICROBES AND INFECTIONS, 2015, 10(6): 374-380.
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http://jmi.fudan.edu.cn/EN/     OR     http://jmi.fudan.edu.cn/EN/Y2015/V10/I6/374
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