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Role of AUF1 in viral infection and related inflammation |
DUAN Chunbin, YANG Tianying, ZHONG Zhaohua |
Department of Microbiology, Harbin Medical University, Harbin 150081, China |
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Abstract Regulated messenger RNA (mRNA) decay is an essential mechanism that governs proper control of gene expression. AU-rich element RNAbinding factor 1 (AUF1) exhibits the characteristics of a transacting factor contributing to the rapid turnover of many cellular mRNAs. AUF1 controls the process of inflammation by mediating inflammatory cytokines and their responses. Studies show that AUF1 binds the internal ribosome entry site (IRES) of enterovirus 71 (EV71) and interacts with IRES to negatively regulate viral translation and replication. AUF1 could be recruited to the stress granules induced by coxsackievirus B3 and enterovirus 71.
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Received: 01 December 2015
Published: 25 February 2016
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Corresponding Authors:
Zhao-Hua Zhong
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[1] |
YANG Han1, HUANG Kaifeng1, XU Su2, ZHAO Huanqiang1, XU Xiaogang2, HU Fuping2, HE Chunyan1, Gong Fang3, LIU Qingzhong1. Effects of culture conditions on transcriptional expression of leukocidin ED of Staphylococcus aureus[J]. JOURNAL OF MICROBES AND INFECTIONS, 2019, 14(1): 23-29. |
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