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| Etiological and epidemiological characteristics of hospitalized children with hand, foot and mouth disease in Shanghai, 2014 |
| WANG Xiangshi, GE Yanling, CAI Jiehao, CHANG Hailing, LI Yuefang, XIA Aimei, ZHU Qirong, ZENG Mei |
| Department of Infectious Disease, Children’s Hospital of Fudan University，Shanghai 201102, China |
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Abstract The purpose of the present study is to monitor the etiological and epidemiological characteristics of hospitalized children with hand, foot and mouth disease (HFMD) in Shanghai, 2014. The stool samples, epidemiological and clinical data of hospitalized children with HFMD in Children’s Hospital of Fudan University were collected in 2014. One-step real-time fluorescence quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and nested PCR were performed for enterovirus detection and typing. Among 19 622 children with HFMD, 1 059 (5.4%) were hospitalized and 547 inpatients were included into this study. Enterviruses were confirmed virologically in 448 (81.9%) children and nine types of enteroviruses were identified. EV71 was more prevalent during February and July; CA16 was relatively prevalent during June and September; CA6 was sporadic from January to July, but prevalent during August and December. One hundred and sixty-two (29.6%) cases had close contact with children suffering from HFMD or herpangina. Two hundred and ten (19.8%) cases were confirmed as severe cases with meningitis or encephalitis. The detection rates of EV71, CA16 and CA6 were 30.3% (70/231), 1.2% (1/83) and 0.9% (1/115)in severe cases, respectively. The results showed that HFMD was prevalent in Shanghai, 2014, and peaked in summer and autumn. Multiple enteroviruses co-circulated in HFMD children. Most cases had no definite exposure history. EV71, CA6 and CA16 were the predominant viruses causing the epidemics of HFMD in Shanghai, 2014, and EV71 remained the major cause for severe diseases.
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Received: 03 February 2016
Published: 25 August 2016
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Corresponding Authors:
ZENG Mei
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2016, Vol. 11 
