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| Advances in intracellular DNA sensors of PYHIN family and mechanisms of viral evasion of innate immune responses |
| WEI Wei1, WANG Sufei1, NI Ming2, YU Bing1 |
| 1. Department of Pathogen Biology, School of Basic Medicine, Huazhong University of Science and Technology, Wuhan 430030, China；2. Department of Infectious Diseases, Tongji Hospital of Huazhong University of Science and Technology, Wuhan 430030, China |
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Abstract The intracellular DNA sensors in host cells recognize viral nucleic acid and activate the innate immunity, then resulting in antiviral effects. However, the viral pathogens have also evolved with appropriate strategies to evade or suppress the innate immune responses. In this review, the characteristics and molecular mechanisms of the immune effects of PYHIN family, one of the DNA sensors in host cells that could recognize viral DNA and activate innate immunity are discussed. The strategies of how viruses escape from the immune surveillance are also summarized.
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Received: 23 July 2016
Published: 25 August 2016
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Corresponding Authors:
Yu Bing
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2016, Vol. 11 
