|
|
Application of CRISPR/Cas9 gene editing technology in tumorigenic virus infection |
WANG Yu, XU Weizhen, ZHONG Zhaohua |
Department of Microbiology and Wu Lien-Teh Institute, Harbin Medical University, Harbin 150081, China |
|
|
Abstract Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) (CRISPR/Cas9) gene editing technology was originated from the study of microbial CRISPR adaptive immune system, by using a specific guide RNA to identify target genes and guide endonuclease of Cas9. Some viral genomes are integrated into the cellular genome or lurk in the organization resulting in persistent infection. This review refers to the latest research results since 2013, focusing on the applications of CRISPR/Cas9 technology in tumorigenic virus infection, such as human immunodeficiency virus type 1 (HIV-1), human papillomavirus (HPV), hepatitis B virus (HBV), and Epstein-Barr virus (EBV).
|
Received: 01 December 2016
Published: 25 April 2017
|
Corresponding Authors:
ZHONG Zhaohua
|
|
|
|
|
|
|