|
|
Dendritic cells and Cryptococcus neoformans |
FANG Wei; XU Rui-Hong; LIAO Wan-Qing |
Department of Dermatology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China |
|
|
Abstract Cryptococcus neoformans is an important fungal pathogen in clinical practice. Dendritic cells (DCs) are the most powerful antigen-presenting cells , which function as the central link between innate and adaptive
immune responses. They are important in recognizing a variety of pathogens, presenting antigens, and inducing immune responses. Many investigations demonstrate that DCs can effectively recognize cryptococcal antigens through several receptors on the cellular surface and promote valid cell-mediated immune responses against invasive microbes. Meanwhile, DCs themselves have shown a certain capacity to kill Cryptococcus neoformans ; however , subset type or the maturation status of DCs can significantly affect the host immune defense . On the other hand, Cryptococcus neoformans has some virulence factors, which can inhibit the induction of protective immune responses, although mannoproteins have been identified as the main immunodominant antigens in Cryptococcus neoformans . In this article , the complicated mechanisms of interplay between DCs and Cryptococcus neoformans in recent years are reviewed.
|
Received: 04 June 2009
Published: 25 March 2010
|
Corresponding Authors:
LIAO Wan-Qing
E-mail: liaowanqing@sohu.com
|
|
|
|
[1] |
WANG Yongrong1, LIAN Yaru1,2, JIANG Guorun1, FAN Shengtao1, FENG Min1, YANG Erxia2, JIANG Li2, DONG Chenghong2, ZHAO Zhimei1, WANG Lichun1, LIAO Yun1, ZHANG Ying1, LI Qihan1. Relationship between coxackievirus A16 antigen and innate lymphoid cells in respiratory tract epithelia and immunological analysis of its vaccine development[J]. JOURNAL OF MICROBES AND INFECTIONS, 2018, 13(6): 350-361. |
|
|
|
|