Epstein-Barr virus (EBV) is the first virus found in humans to be associated with tumorigenesis. More and more studies have found that EBV infection is closely related with the occurrence, development, treatment and prognosis of some lymphomas. To date, although the application of antiviral drugs and immunotherapy is rapidly developed, the treatment against EBV-positive lymphomas is still mainly based on radiotherapy and chemotherapy. To strengthen the research on EBV and EBV-related lymphomas, and seeking effective prevention or treatment strategies against EBV infection, will be expected to improve the prognosis of patients with EBV-positive lymphomas.