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| Progress on PINK1/parkin pathway-mediated mitophagy |
| LANG Xiujuan, WANG Yan |
| Department of Microbiology, School of Basic Medical Sciences, Harbin Medical University, Harbin 150081, China |
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Abstract Mitophagy is a special version of autophagy which eliminates damaged or redundant mitochondria effectively and selectively. Eukaryotes conduct mitochondrial quality control via mitophagy to maintain the function of the power-generating organelles. Recently, a series of studies have demonstrated that two Parkinson’s disease-related genes, PINK1 and parkin, were involved in mitophagy. Parkin and PINK1 cooperate with each other to recognize damaged mitochondria specifically. Particularly, ubiquitin and deubiquitinases play essential roles in modulating parkin activity and mitophagy efficiency. Here we introduce and review the recent studies on PINK1/parkin pathway in mitophagy.
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Received: 04 September 2017
Published: 25 April 2017
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Corresponding Authors:
WANG Yan
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2018, Vol. 13 
