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Research advances in therapeutic anti-tuberculosis vaccines |
SHEN Hong-Bo; WANG Hong-Hai |
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China |
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Abstract Therapeutical anti-tuberculous vaccines were mainly used to immunize patients infected by Mycobacterium tuberculosis, including those with latent tuberculosis infection and those receiving drug therapy. Therapeutical vaccine can reverse the non-protective immune response to Th1 type response in patients. It can induce the Mycobacterium tuberculosis antigen-based cell immunity and elicit cytotoxic T cell activity to eliminate the bacteria in cells. Therapeutical anti-tuberculous vaccine would help to prevent the recrudescence of latent tuberculosis. It also could enhance the efficiency of drugs to kill Mycobacterium tuberculosis, especially drug-resistant Mycobacterium tuberculosis.
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Received: 21 April 2010
Published: 25 June 2010
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Corresponding Authors:
WANG Hong-Hai
E-mail: hhwang@fudan.edu.cn
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