The present article introduces a regional health service union which was built by The Fifth People’s Hospital of Shanghai and based on the former medical joint venture, to control chronic diseases, including chronic respiratory infections, chronic liver diseases, diabetes mellitus and strengthen health education. The establishment of this regional health service union was based on a joint collaborative project between Fudan University and Minhang District government, named SMART Information Technology. Currently, the goal of this health service union is to prevent the progress of serious diseases as early as possible, monitor the progress of chronic diseases by certain convenient and inexpensive measures and carry out demographic health education. Hopefully, these approaches will enhance reasonable distribution of high-quality medical services, and the life-long healthcare will be developed for community residents. The Fifth People’s Hospital of Shanghai has worked out this sustainable model for healthcare in Minhang District, named as “health service union”， which may be applied in other districts in the future.