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| Understanding the underlying pathogenesis of Alzheimer’s disease from the perspective of gut microbiota |
| WANG Hong1, NIU Chen1, WANG Huijing2, ZHAO Chao1,3 |
| 1. MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical sciences, Shanghai Medical College, Fudan university, Shanghai 200032, China; 2. Laboratory of Neuropsychopharmacology, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China; 3. National Clinical Research Center on aging and medicine, Huashan Hospital, Shanghai 200041, China |
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Abstract In the past decade, it has been realized that the diversity and balance of the gut microbiota plays a critical role for health. Gut microbiota and their metabolites interact with the host through a series of biochemical, immunological and physiological processes to affect the homeostasis and health of the host. Many studies have been reported that the disorders of the gut microbiota are associated with neurological diseases. Alzheimer’s disease (AD) is a complex neurodegenerative disease, its susceptibility and development are influenced by age, heredity and epigenetic factors. New evidence suggested that the composition change and translocation of the gut microbiota were associated with the development of AD, but its causal relationship and possible mechanisms need to be explored. Communications between the central nervous system and the gut axis relied mainly on three manners, including direct neural communication, endocrine pathways and immune regulation. Evidence from animal models of fecal microbiota transplantation and probiotic intervention suggested the association of gut microbiota with AD. Exogenous bacterial metabolites can directly impair neuronal function, and induce neuroinflammation to promote the onset of AD. In this review, we focused on the relationship and possible mechanisms of gut microbiota with AD, and provided evidence for possible interventions to prevent AD by improving the structure of gut microbiota.
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Received: 28 February 2019
Published: 25 October 2019
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Corresponding Authors:
ZHAO Chao
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2019, Vol. 14 
