As an important component of the intestinal microbial community, phage has colonized in the intestinal tract in a relatively stable state in different life stages. The currently known intestinal phages are mainly DNA phages, most of which exist in the form of prophage. The intestinal phageome can optimize the structure and composition of the microbiota through various mechanisms, and its structural changes are related to various diseases. This paper reviews the research progress of intestinal phage group and human health, and prospects the research methods and development direction in this field.