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Progress on oncolytic mechanism of enteroviruses |
WANG Shilin, MENG Tianjiao, SHANG Qinglong |
Department of Microbiology, Harbin Medical University, Harbin 150081, Heilongjiang Province, China |
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Abstract As infection by enteroviruses being asymptomatic or causing mild lesions in human beings, enterovirus-based oncolytic viruses have received extensive attentions. A large number of experimental results demonstrated that it is safe and effective way to use enterovirus to treat tumor. The oncolytic mechanism of different enterovirus remains open. In this paper, the molecular mechanism of oncolytic enterovirus, modification of enterovirus and clinical trials are reviewed.
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Received: 29 October 2019
Published: 25 April 2020
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Corresponding Authors:
SHANG Qinglong
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