Analysis of hepatitis B virus serological characteristics in occult hepatitis B virus infection among blood donors

LV Ying1、3, WU Xiaofei2, MAO Richeng1, JIA Yao2, ZHANG Jiming1, WANG Xun2

Journal of Microbes and Infections ›› 2020, Vol. 15 ›› Issue (3) : 166-171.

PDF(533 KB)
Welcome to visit Journal of Microbes and Infections, April 4, 2025
PDF(533 KB)
Journal of Microbes and Infections ›› 2020, Vol. 15 ›› Issue (3) : 166-171. DOI: 10.3969/j.issn.1673-6184.2020.03.005
Original Article

Analysis of hepatitis B virus serological characteristics in occult hepatitis B virus infection among blood donors

  • LV Ying1、3, WU Xiaofei2, MAO Richeng1, JIA Yao2, ZHANG Jiming1, WANG Xun2
Author information +
History +

Abstract

The purpose of this study is to analyse the hepatitis B virus(HBV) serological characteristics in occult hepatitis B virus infection (OBI) among blood donors. We selected 395 nucleic acid test positive blood samples and 523 nucleic acid test negative blood samples from 2013 to 2018 in Shanghai Blood Center, which were with normal ALT and with HBsAg,anti-HCV and HIV antigen-antibody negative. Nucleic acid test positive samples were tested by HBV DNA identification reagent with PCR or transcription-mediated amplification ( TMA) essays. HBV serological markers were tested by chemiluminescent method in all of the samples. We found that among 395 nucleic acid test positive samples, 197 were positive for HBV DNA identification, which were considered to be OBI. Most of the OBI samples were positive for anti-HBc (85.79%). The main serological patterns in OBI were anti-HBs positive and anti-HBc positive or anti-HBc positive alone. The main serological patterns in the qualified blood donors were seronegative and anti-HBs positive,. The level of anti-HBs in the OBI group was significantly lower than that in the qualified blood donors group (Z =-0.198, P < 0.05). The level of anti-HBs in OBI group was mainly lower than 100 mIU / mL. However, the proportion of high anti-HBs level (> 1000 mIU/mL) in qualified blood donor group was higher than that in the OBI group (P < 0.05). It indicated that the HBV serological markers in most of the occult HBV infected people in Shanghai area are different from the qualified blood donors.

Key words

Hepatitis B virus / Occult hepatitis B virus infection / Nucleic acid testing / Serological markers / Qualified blood donors

Cite this article

Download Citations
LV Ying1、3, WU Xiaofei2, MAO Richeng1, JIA Yao2, ZHANG Jiming1, WANG Xun2. Analysis of hepatitis B virus serological characteristics in occult hepatitis B virus infection among blood donors[J]. Journal of Microbes and Infections. 2020, 15(3): 166-171 https://doi.org/10.3969/j.issn.1673-6184.2020.03.005
PDF(533 KB)

Accesses

Citation

Detail

Sections
Recommended

/