Current research progress on host innate immune escaping by Salmonella

XU Nuo1; ZHOU Bangyue1; SHI Yi1; PAN Xingyuan1; 2; QIN Tao3; XU Zhengzhong4; YIN Yinyan1; 2; 4

doi:10.3969/j.issn.1673-6184.2020.05.010

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Journal of Microbes and Infections ›› 2020, Vol. 15 ›› Issue (5) : 331-336. DOI: 10.3969/j.issn.1673-6184.2020.05.010

Review

Current research progress on host innate immune escaping by Salmonella

XU Nuo¹, ZHOU Bangyue¹, SHI Yi¹, PAN Xingyuan^1，2, QIN Tao³, XU Zhengzhong⁴, YIN Yinyan^1，2，4

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Abstract

Salmonella is an important foodborne pathogen, which seriously threatens the global public health. The host innate immune response plays a significant role for resisting infection. Nowadays, Salmonella has evolved a series of strategies to escape the innate immune response for persistent infections. This review gives a detailed summarization on the new strategies of Salmonella, including receptors (TLRs, NLRs, RIPs), cytokines (IL-22 and IL-4) and mTOR signaling pathway-mediated immune escape.

Key words

Salmonella / Immune evasion / Toll like receptor / Nucleotide binding oligomerization domain like receptor / Cytokines / Mammalian target of rapamycin signaling pathway

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XU Nuo1, ZHOU Bangyue1, SHI Yi1, PAN Xingyuan1，2, QIN Tao3, XU Zhengzhong4, YIN Yinyan1，2，4. Current research progress on host innate immune escaping by Salmonella[J]. Journal of Microbes and Infections. 2020, 15(5): 331-336 https://doi.org/10.3969/j.issn.1673-6184.2020.05.010