Coronavirus disease 19 (COVID-19) related studies that were published on journals and medRxiv were reviewed to explore effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on extrapulmonary organs and its potential mechanisms. In addition to respiratory organs, the expression of SARS-CoV-2 functional receptor has also been observed in human hearts, gut, liver, kidneys, and central nervous systems. The action of SARS-CoV-2 on extrapulmonary receptors may contribute to multiple organ dysfunction and the high mortality rate of COVID-19. However, the exact mechanism leading to extrapulmonary impairments in COVID-19 patients remains elusive and further research is needed to provide more evidence.