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| The application of organoid tissue model in the pathogen infection diseases |
| ZHANG Shuxin, CAI Qiliang, ZHU Caixia |
| MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China |
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Abstract Organoid is a multicellular cluster formed by tissue stem cells cultured in 3D in vitro, which has the ability of self-proliferation and multi-directional differentiation. Due to it is similar to the gene, structure and function of the source organ in space and structure, it can be used to simulate the growth, differentiation and organ formation process of tissue cells in vivo, drug screening and evaluation, biomedical materials and tissue engineering. Increasing evidence shows that different kinds of organs and tissues can be used to simulate the process of pathogen invasion in vitro. This review summarizes the research progress and application prospect of organoids model in pathogenic infection related diseases.
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Received: 16 April 2020
Published: 25 June 2021
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Corresponding Authors:
CAI Qiliang, ZHU Caixia
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2021, Vol. 16 
