The pandemic of 2019 coronavirus disease (COVID-19) caused by the 2019 novel coronavirus (2019-nCoV), also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a serious threat to global public health and economic development. Vaccines and antiviral drugs are important means for combating the epidemic. Most of the vaccines and therapeutics currently being developed are specific for SARS-CoV-2, which may become ineffective if the virus makes major mutation(s) or another highly pathogenic coronavirus emerges. Because the development of a vaccine and a new antiviral drug is often lagging behind, it is difficult to put them into use quickly in the early stage of the outbreak. Therefore, it is an urgent need to develop efficient, safe and broad-spectrum anti-coronavirus vaccines and drugs to combat the possible outbreaks of new coronavirus disease in the future. Here we review the progress of research and development of broad-spectrum anti-coronavirus vaccines and peptides, providing our opinions and suggestions on the development of such vaccines and therapeutics.