Abstract Salmonella infection which generally spread via food, is a serious threat to human health. As an important barrier against Salmonella invasion, intestinal epithelial cells reduce the colonization and invasion of Salmonella in multiple ways. At the same time, intestinal mononuclear phagocytes also recognize Salmonella through NAIP which activate NLRC4 inflammasome to induce pyroptosis and Salmonella elimination. Caspases are a family of cysteine-aspartic proteases that carry out a variety of cellular functions. Pyroptosis mediated by Caspase-1 is the key component of inflammasomes, which induces pyroptosis by cleaving GSDMD. Previous research found that, just like caspase-1, caspase-8 was also recruited by inflammasomes, but its function was unclear. Recent research revealed that, when pyroptosis was inhibited, Caspase-8 could be strongly activated in inflammasomes which protected against Salmonella infection. Therefore, to explore the mechanism of caspase-8 in regulating host cell death during Salmonella infection is of great significance for further understanding the relationship between Salmonella infection and host anti-infection immune response.
Received: 31 August 2020
Published: 01 January 2022