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| Inactivated vaccine protects against severe outcome among adults aged over 60 years during SARS-CoV-2 Omicron variant predominance: evidence from a single-center cohort |
| SUN Feng1, ZHANG Yilin1, LI Yang1, ZHANG Haocheng1, LIU Qihui1, AI Jingwen1, WANG Sen1, CUI Shuzheng2, SHI Liubin2, XUE Yu2, LONG Feng2, MA Ke2, QIN Lunxiu2, ZHANG Jiming1, ZHANG Wenhong1 |
| 1. Department of Infectious Diseases, National Clinical Research Center for Aging and Medicine, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai 201907, China; 2. Huashan Hospital, Baoshan Campus, Fudan University, Shanghai 201907, China |
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Abstract The purpose of the current study is to investigate the association between vaccination status and clinical outcomes in the elderly during the Omicron wave. A total of 1 029 patients aged 60 years or older were hospitalized in Huashan Hospital of Fudan University, Baoshan Campus from March 20 to May 6, 2022 (643 cases unvaccinated, 386 cases vaccinated). Demographic characteristics, clinical symptoms, laboratory findings, and clinical outcomes were compared, and multivariate regression was applied to determine association between vaccination status and clinical outcomes. Results indicated a significant difference in age, BMI, comorbidity (diabetes, cardiovascular disease, chronic kidney disease), number of comorbidities, and laboratory findings (lymphocyte counts, C-reactive protein, D-dimer, ALT, creatinine, pro-BNP and troponin) between unvaccinated and vaccinated patients (P<0.05). Unvaccinated patients were more likely to experience COVID-19-related outcomes, including pneumonia (51.6% vs 26.2%), respiratory support [40.7% vs 13.5%], invasive ventilation or death [6.2% vs 0.7%]. Multivariate regression analysis showed that vaccination was associated with early virus shedding [aHR＝1.594, 95%CI (1.259, 2.017)], and protected against progression to pneumonia [aOR＝0.501, 95%CI (0.370, 0.678)], respiratory support [aOR＝0.336, 95%CI (0.232, 0.487)], invasive ventilation or death [aOR＝0.190, 95%CI (0.052, 0.687)] in elderly patients. Our findings suggest that inactivated vaccine protects against COVID-19-related severe outcomes in individuals aged over 60 years.
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Received: 06 June 2022
Published: 25 August 2022
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Corresponding Authors:
ZHANG Jiming
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2022, Vol. 17 
