Recent progress on cell receptors for SARS-CoV-2

CHEN Shenglin1*, XIAO Man2*, LI Zhaozhong3, XU Zhikai1, HAN Qi1, FENG Dongfang1, DENG Yan1, YIN Zuoming1

Journal of Microbes and Infections ›› 2023, Vol. 18 ›› Issue (1) : 46-54.

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Journal of Microbes and Infections ›› 2023, Vol. 18 ›› Issue (1) : 46-54. DOI: 10.3969/j.issn.1673-6184.2023.01.006
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Recent progress on cell receptors for SARS-CoV-2

  • CHEN Shenglin1*, XIAO Man2*, LI Zhaozhong3, XU Zhikai1, HAN Qi1, FENG Dongfang1, DENG Yan1, YIN Zuoming1
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Abstract

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of the coronavirus disease 2019(COVID-19), which spreads rapidly in humans and endangers global health and economy. There are no specific and effective antiviral drugs for the treatment of COVID-19 currently. To infect host cells successfully for a virus, receptor binding and virus internalization are considered to be the initial steps. A key to combat SARS-CoV-2 infection is to investigate the viral receptors, which determine its infectivity and host range. The discovery and identification of cell receptors for SARS-CoV-2 will provide new therapeutic targets for COVID-19. This article reviews the recent findings on the entry and attachment receptors for SARS-CoV-2.

Key words

Severe acute respiratory syndrome coronavirus 2 / Entry / Receptor / Attachment receptor / Spike / Receptor-binding domain

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CHEN Shenglin1*, XIAO Man2*, LI Zhaozhong3, XU Zhikai1, HAN Qi1, FENG Dongfang1, DENG Yan1, YIN Zuoming1. Recent progress on cell receptors for SARS-CoV-2[J]. Journal of Microbes and Infections. 2023, 18(1): 46-54 https://doi.org/10.3969/j.issn.1673-6184.2023.01.006
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