The clinical microbiology laboratory of the First Affiliated Hospital of Hainan Medical University isolated and cultured a Gram-negative bacillus strain from the wound secretion of a patient with left tibial plateau fracture on June 16, 2022, which was confirmed to be Salmonella entrica subsp. enterica serotype enteritidis by automatic microbial identification system and matrix-assisted laser desorption / ionization time of flight mass spectrometry(MALDI TOF-MS)experiments. The patient was treated with meropenem 1.0 g q8h intravenous drip for 9 d. According to the results of etiological detection and drug susceptible test, the following medication regimen was adopted: piperacillin tazobactam sodium 4.5 g q6h intravenous drip for 5 d, meropenem 1.0 g q8h intravenous drip for 19 d, vancomycin 1.0 g q12h intravenous drip for 10 d, and debridement and drainage of left tibial plateau infection, the patient was cured and discharged.