Mechanism of interferon-γ-mediated anti-Chlamydia infection

TANG Guo-Fang; LI Zhong-Yu; WU Yi-Mou

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Journal of Microbes and Infections ›› 2009, Vol. 4 ›› Issue (2) : 103-107.

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Mechanism of interferon-γ-mediated anti-Chlamydia infection

TANG Guo-Fang；LI Zhong-Yu；WU Yi-Mou

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Abstract

Chlamydia is an intracellular bacterium that infects many vertebrates, including humans. Previous studies have shown that interferon-γ(IFN-γ) plays an important role in defense against Chlamydia infection. IFN-γ-mediated anti-Chlamydia effector mechanisms may include the exhaustion of tryptophan, the induction of iron loss, and/or the activation of inducible nitric oxide synthase (iNOS). However, Chlamydia has evolved to develop mechanisms to escape IFN-γ functions. In this review, we will discuss IFN-γ-mediated effector mechanisms in the control of Chlamydia infection.

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TANG Guo-Fang；LI Zhong-Yu；WU Yi-Mou. Mechanism of interferon-γ-mediated anti-Chlamydia infection[J]. Journal of Microbes and Infections. 2009, 4(2): 103-107