Role of autophagy in bacterial infections and immune responses

LI Qiong; WU Shu-Yan; HUANG Rui

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Journal of Microbes and Infections ›› 2009, Vol. 4 ›› Issue (2) : 108-111.

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Role of autophagy in bacterial infections and immune responses

LI Qiong；WU Shu-Yan；HUANG Rui

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Abstract

Autophagy is an important form of programmed cell death that regulates the growth and development of cells. It acts as a ‘two-edge sword’. On one side, autophagy eliminates microbes; on the other, many bacteria have developed distinct mechanisms to regulate and interfere with autophagy for their own replication and survival. Autophagy is an important event in the innate immune response. It can initiate a response to bacteria and bacterial toxins through Toll-like receptor mechanisms or mucosal immune system. Effector cells of the cellular immune system can regulate autophagy by secreting different cytokines, allowing the organism to re-tune its adaptive immune response. Autophagy may play a pivotal role in regulating the immune polarization of Th1/Th2 in fighting intracellular bacteria.

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Autophagy / Bacteria / Immune response

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LI Qiong；WU Shu-Yan；HUANG Rui. Role of autophagy in bacterial infections and immune responses[J]. Journal of Microbes and Infections. 2009, 4(2): 108-111