Ureaplasma urealyticum whose pathogenicity is still controversial is a common micro-organisms of female urogenital mucosa.Lower genital tract infection of ureaplasma urealyticum can cause non-gonococcal urethritis or cervicitis mucus, while in the respiratory tract context, Ureaplasma urealyticum can induce neonatal pneumonia, bronchopulmonary dysplasia, chronic lung disease and so on.For the study of pathogenesis of Ureaplasma urealyticum infection, host immune response, as well as development of prevention and treatment of Ureaplasma urealyticum infection in drug experiments, animal model is indispensable.At home and abroad a variety of Ureaplasma urealyticum whose pathogenicity is still controversial is a common micro-organisms of female urogenital mucosa.Lower genital tract infection of ureaplasma urealyticum can cause non-gonococcal urethritis or cervicitis mucus, while in the respiratory tract context, ureaplasma urealyticum can induce neonatal pneumonia, bronchopulmonary dysplasia, chronic lung disease and so on.For the study of pathogenesis of ureaplasma urealyticum infection, host immune response, as well as development of prevention and treatment of ureaplasma urealyticum infection in drug experiments, animal model is indispensable.At home and abroad a variety of Ureaplasma urealyticum animal models have been successfully established.Estradiol pretreatment is essential for the animal model of Ureaplasma urealyticum reproductive tract infection, , and BALB / c mice is the preferred experimental animals, while ureaplasma urealyticum respiratory tract infection model does not need estrogen pretreatment, a number of scholars have used C3H/HeN mice to establish the model successfully. animal models have been successfully established.Estradiol pretreatment is essential for the animal model of Ureaplasma urealyticum reproductive tract infection, , and BALB / c mice is the preferred experimental animals, while Ureaplasma urealyticum respiratory tract infection model does not need estrogen pretreatment, a number of scholars have used C3H/HeN mice to establish the model successfully.