Autophagy plays an important role in the innate and adaptive i mmune . On one hand, it acts as an innate i mmune response when eli minating microbes in cells vialysosome degradati on ; on the other hand, it acts effectively in adaptive i mmunity by regulating antigen processing and presentation. Autophagy is not only involvedin and enhances major histocompatibility complex ( MHC) II antigen presentation , but it also assists with classic and nonclassic MHCI antigen presentati on .