1 043 Staphylococcus aureus (S. aureus) strains isolated from 1 416 skin lesions collected from children visiting the clinic for the first time with infectious skin diseases at thirteen Children’s Hospital in China were subjected to a drug susceptibility test by agar dilution method. The mecA gene and the genotypes of Staphylococcal chromosome cassette mec (SCCmec) were identified by polymerase chain reaction (PCR). The results demonstrated that the drug resistance rates were97.3% of the isolated s to erythromycin,96.7% to penicillin, 89% to clindamycin,42.2% to tetracycline, 15% to chloramphenicol, 9.8% to gentamicin, 6.6% to ciprofloxacin, 4.6% to trimethoprim/sulfamethoxazole, 3.4% to oxacillin, 3.1% to cefuroxime, 2.4% to rifampin, 1.7% to ceftriaxone, 1.6% to cefazolin, 1.3% to fusidic acid and 0.8% to mupirocin. None of the isolated S. aureus strains were resistant to vancomycin. The prevalence of community-acquired methicillin-resistant S. aureus (CA-MRSA) was 3.4%，and all the 35 strains were mecA-positive. SCCmec Ⅳ and V were identified in 14 and 19 isolates respectively.. Two isolates were non-typable. The results suggest that effective antibiotic agents for children with infectious skin diseases are oxacillin, cephalosporin, fusidic acid, trimethoprim/sulfamethoxazole, rifampin,and vancomycin. Mupirocin is the selection for topical application.The mecA gene was detected in 100% of 35 CA-MRSA strains from children with infectious skin diseases in China. SCCmec Ⅳ and SCCmec Ⅴ are the major genotype.