Abstract: In recent 70 years, the wide use of antibiotics leads to the increasing drug-resistance bacteria. In America, from 1999 through 2005, estimated MRSA-related hospitalizations more than doubled, and MRSA-related hospitalizations with a diagnosis code for septicemia increased 81.2%. Therefore, it is urgent to seek novel countermeasures, which include antibacterial peptide and bacteriophage at present, to control drug-resistance bacteria. Despite bacteriophage was discovered earlier, it was ignored owing to antibiotic popularity. But now, bacteriophages come back into view as a result of increasing drug-resistance bacteria. Here, we introduce the research progress on bacteriophage and lysin control of Staphylococcus aureus.