Adult acute infectious diarrhea is different from children infectious diarrhea in incidence, severity and prognosis. Fluid infusion and antidiarrheal treatment are given priority to antibiotics. In recent years, there are some new and updated evidence-based medical evidence in fluid infusion, probiotics and new antidiarrheal medicines for adult acute infectious diarrhea, which in further ensures the safety of the existing drugs, offers more choices and improves our understanding of the treatment of diarrhea.