High-risk human papillomavirus (HPV) could integrate into host cell genome in some tumors such as cervical carcinoma. Epidemiological and experimental data support that high-risk HPV genome integration plays an important role in cervical carcinogenesis. High-risk HPV genome integration may have close relationship with chromosome instability and DNA methylation. In recent years, clone selection is relative to interferon pathway. The impact on the function of several genes by integration and integration sites detection are in progress. Here the recent researches on high-risk HPV integration are reviewed.