A case of penicilliosis marneffei complicated with lymph node tuberculosis was reported. The boy was born in December 2010 and admitted for swollen lymph nodes behind the ear lasting for more than two years and aggravation with recurrent fever for 5 months. The human immunodeficiency virus (HIV) test was negative. He was treated with a variety of antibiotics but ineffective. After administration of anti­tuberculosis drugs, his body temperature temporarily returned to normal, but recurrent fever appeared. We considered the presence of fungal infections and treated him with voriconazole. The condition of the child was improved significantly. The culture of his bone marrow sample turned positive for Penicillium marneffei. The boy was diagnosed lymph node tuberculosis by lymph node biopsy. The clinical presentation, diagnosis and treatment of penicilliosis marneffei complicated with tuberculosis were discussed in the context of the literatures.