Acquired immunodeficiency syndrome (AIDS), still a serious infectious disease, causes global epidemic and remains incurable until now. The current available antiretroviral therapy successfully inhibits human immunodeficiency virus (HIV) replication, but can not eradicate the genome-integrated HIV. Recently, genome editing techniques, such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) (CRISPR-Cas system), have been found to successfully disrupt the integrated HIV-1 genes. Furthermore, genome editing techniques also have successfully induced C-C chemokine receptor type 5 (CCR5) ?32 mutation, a mutation of HIV entry coreceptor CCR5 that is resistant to HIV infection. Therefore, genome editing techniques bring the glimmers of success in eradication of HIV in human bodies.