Multiple-­drug resistant Klebsiella pneumonia strains collected from several hospitals in Shanghai were used as the host bacteria to isolate phages in the wastewater. A novel phage KP002 was isolated and analyzed in details. The morphology and size of the bacteriophage was observed by electron microscope with negative staining. The results indicated that it was a tailed phage with head diameter about 70 nm, tail length about 80 nm and tail width about 20 nm. This phage had high activity at pH from 3 to 9 and temperature from 4 to 50 ℃. The adsorption rate was above 95% within 6 min. Its incubation period was 10 min and burst period was 50 min. The burst size reached 172 pfu/cell. The whole genome sequence showed that it contained a circular double­-stranded DNA with a full­length of 47 173 bp and GC content of 48%. KP002 is a new phage against drug­-resistant bacteria and could be served as a potential resource for clinical treatment of multiple­-drug resistant bacterial infection.