A case of Pasteurella canis meningitis and ependymitis in an 8-­month-­old infant was reported. The patient had a history of 5-­day fever and 2­-day convulsion before the admission, and Pasteurella canis was detected from clinical samples. Although timely treatment with a panel of sensitive antibiotics was administered after hospital admission, the conditions continued to progress with cerebral hemia, central respiratory failure and death. This case demonstrates that a rare bacterial infection may cause serious conditions to infants and parents should keep their children away from potential dangerous situations.