Enterovirus 71 (EV71) is a pathogen for hand, foot and mouth disease (HFMD), and its prevalence is a great challenge to public health. Pathogenesis of EV71 is closely related to a panel of host innate immune responses, such as escape of interferon response, suppression of nuclear factor κB (NF­-κB) signaling pathway and interactions between virus and innate immune cells. This review focuses on the new progress on interactions between EV71 and host innate immunity.