Chikungunya fever is a mosquito-borne infectious disease caused by chikungunya virus, with high infection rate and persistent joint pain. In recent years, outbreak of chikungunya fever increased with expanding epidemic scope, leading to one million infected cases each year worldwide. Meanwhile, some chikungunya virus genotypes have gained some mutations which result in more effectively spread by Aedes albopictus. So it poses a potential threat to the residents not only in tropical and subtropical regions, but also in temperate regions with Aedes albopictus.