To improve the understanding of the clinical manifestations and dangers of liver abscess invasive syndrome caused by Klebsiella pneumoniae (K. pneumoniae) infection, the clinical courses, including treatment and outcomes of three cases were retrospectively analyzed. All infections were community-acquired. Their clinical manifestations and blood culture test results were in line with the clinical features of liver abscess invasive syndrome caused by K. pneumoniae infection. All had liver abscesses; two cases had complications with endophthalmitis leading to blindness; one patient was complicated with lumbar and abdominal aortic infection and infectious endocarditis. Two patients had diabetes history, and one patient was normal immunocompetent. The liver abscess invasive syndrome caused by K. pneumoniae infection should get more clinical attentions because it is hard to treat and may cause serious clinical dangers, not only liver abscess but also extrahepatic disseminated lesions. It is detected not only in diabetic and immunodeficient populations but also in the normal immunocompetent population.