Epidemics of scarlet fever started in China in 2011. Most of the cases were represented by the classic type, while the surgical type was rarely reported. It is unclear whether ICE-emm12 and ΦHKU.vir, the two mobile genetic elements firstly discovered in the strains leading to scarlet fever outbreak in Hong Kong, were carried by the strains in Mainland China. Here we reported a scarlet fever case in Zhejiang which was caused by Streptococcus pyogenes. Strains isolated from the pharynx and skin wound all carried ICE-emm12 and ΦHKU.vir. The result suggests a screening of the two mobile genetic elements in Mainland China for genetic surveillance of scarlet fever.