Since early 2015, Zika virus has caused severe epidemic outbreaks, which started from Brazil involving dozens of regions and countries successively, and contemporaneously growing infants with microcephaly have made the whole global alert against Zika virus. A variety of potential neurological disorders caused by Zika virus infection are under exploring worldwide. The need of treatments for infectors is more and more urgent because of increasing evidences indicating that Zika virus is able to impair the brain development of the embryo in cellular level and animal model. This review will summarize recent research achievements concerning epidemiology and advances among causal relationship with microcephaly, potential preventive vaccines and therapeutic drugs of Zika virus.