Detection rate of Candida tropicalis (C. tropicalis) is increasing in clinical practice. Azole antifungal agents are commonly used in the treatment of C. tropicalis infection because of their low cytotoxicity and oral administration. In China, there is a high rate of isolation of azole resistant C. tropicalis. It is necessary to understand the azole resistance mechanism of C. tropicalis, which may provide a base for new drug targets. At present, the main mechanisms associated with resistance of C. tropicalis to azoles are the overexpression and mutation of the target gene ERG11, the overexpression and mutation of upc2 gene encoding a transcription factor, the overexpression of efflux pump genes and other related genes. In this paper, the current progress on the latest azole resistance mechanism of C. tropicalis is reviewed.