Progress in animal modeling of Nipah virus infection

PDF(1014 KB)

Journal of Microbes and Infections ›› 2024, Vol. 19 ›› Issue (2) : 120-128.

Author information +

History +

Abstract

This review aims to provide a comprehensive overview of the advancements in Nipah virus animal models, enhancing the understanding of Nipah virus infection pathways, pathogenic mechanisms, and the targeted development and evaluation of vaccines and antibodies. Nipah virus is a zoonotic paramyxovirus with a high fatality rate and is classified as a Biosafety Level 4 pathogen. Since its first outbreak in Malaysia in 1998, it has continued to cause epidemics in Southeast and South Asia, leading to severe respiratory diseases and encephalitis in humans and animals, with no approved vaccines or therapeutic drugs currently on the market. The World Health Organization has prioritized Nipah virus disease for research and development. This review summarizes the construction and development of Nipah virus infection animal models, with multiple species having been utilized in the development of Nipah virus infection models, such as golden hamsters, ferrets, pigs, African green monkeys, and guinea pigs, which reflect the symptoms and pathological characteristics of Nipah virus infection to varying degrees, as well as the advantages and limitations of the models. The review also discusses the establishment and application of pseudovirus animal infection models and looks forward to the future direction of Nipah virus animal model research.

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

Progress in animal modeling of Nipah virus infection[J]. Journal of Microbes and Infections. 2024, 19(2): 120-128

References

[1]CHUA K B, BELLINI W J, ROTA P A, et al.Nipah virus: a recently emergent deadly paramyxovirus[J].Science, 2000, 288(5470):1432-5
[2]FIELD H, YOUNG P, YOB J M, et al.The natural history of Hendra and Nipah viruses[J].Microbes Infect, 2001, 3(4):307-14
[3]NEGRETE O A, LEVRONEY E L, AGUILAR H C, et al.EphrinB2 is the entry receptor for Nipah virus,an emergent deadly paramyxovirus[J].Nature, 2005, 436(7049):401-5
[4]GóMEZ ROMáN R, TORNIEPORTH N, CHERIAN N G, et al.Medical countermeasures against henipaviruses: a review and public health perspective[J].The Lancet Infectious Diseases, 2022, 22(1):e13-e27
[5]LO M K, HARCOURT B H, MUNGALL B A, et al.Determination of the henipavirus phosphoprotein gene mRNA editing frequencies and detection of the C,V and W proteins of Nipah virus in virus-infected cells[J].J Gen Virol, 2009, 90(Pt 2):398-404
[6]AMAYA M, BRODER C C.Vaccines to Emerging Viruses: Nipah and Hendra[J].Annu Rev Virol, 2020, 7(1):447-73
[7]ANDERSON D E, ISLAM A, CRAMERI G, et al.Isolation and Full-Genome Characterization of Nipah Viruses from Bats,Bangladesh[J].Emerg Infect Dis, 2019, 25(1):166-70
[8]LUBY S P.The pandemic potential of Nipah virus[J].Antiviral Res, 2013, 100(1):38-43
[9]RAHMAN M A, HOSSAIN M J, SULTANA S, et al.Date palm sap linked to Nipah virus outbreak in Bangladesh,2008[J].Vector Borne Zoonotic Dis, 2012, 12(1):65-72
[10]MISHRA G, PRAJAPAT V, NAYAK D.Advancements in Nipah virus treatment: Analysis of current progress in vaccines,antivirals,and therapeutics[J].Immunology, 2024, 171(2):155-69
[11]YOB J M, FIELD H, RASHDI A M, et al.Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia[J].Emerg Infect Dis, 2001, 7(3):439-41
[12]EPSTEIN J H, PRAKASH V, SMITH C S, et al.Henipavirus infection in fruit bats (Pteropus giganteus),India[J].Emerg Infect Dis, 2008, 14(8):1309-11
[13]CHADHA M S, COMER J A, LOWE L, et al.Nipah virus-associated encephalitis outbreak,Siliguri,India[J].Emerg Infect Dis, 2006, 12(2):235-40
[14]LO PRESTI A, CELLA E, GIOVANETTI M, et al.Origin and evolution of Nipah virus[J].J Med Virol, 2016, 88(3):380-8
[15]SUN B, JIA L, LIANG B, et al.Phylogeography,Transmission,and Viral Proteins of Nipah Virus[J].Virol Sin, 2018, 33(5):385-93
[16]WANG Z, LI Z, SHI W, et al.A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus[J].Sci Adv, 2023, 9(25):e-a
[17]NIE J, LIU L, WANG Q, et al.Nipah pseudovirus system enables evaluation of vaccines in vitro and in vivo using non-BSL-4 facilities[J].Emerg Microbes Infect, 2019, 8(1):272-81
[18]GUILLAUME V, CONTAMIN H, LOTH P, et al.Nipah virus: vaccination and passive protection studies in a hamster model[J].J Virol, 2004, 78(2):834-40
[19]GUILLAUME V, CONTAMIN H, LOTH P, et al.Antibody prophylaxis and therapy against Nipah virus infection in hamsters[J].J Virol, 2006, 80(4):1972-8
[20]DONG J, CROSS R W, DOYLE M P, et al.Potent Henipavirus Neutralization by Antibodies Recognizing Diverse Sites on Hendra and Nipah Virus Receptor Binding Protein[J].Cell, 2020, 183(6):1536-50
[21]WEINGARTL H M, BERHANE Y, CASWELL J L, et al.Recombinant nipah virus vaccines protect pigs against challenge[J].J Virol, 2006, 80(16):7929-38
[22]WONG K T, GROSJEAN I, BRISSON C, et al.A golden hamster model for human acute Nipah virus infection[J].Am J Pathol, 2003, 163(5):2127-37
[23]GUILLAUME V, WONG K T, LOOI R Y, et al.Acute Hendra virus infection: Analysis of the pathogenesis and passive antibody protection in the hamster model[J].Virology, 2009, 387(2):459-65
[24]DOYLE M P, KOSE N, BORISEVICH V, et al.Cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein[J].Cell Rep, 2021, 36(9):109628-109628
[25]DE WIT E, MUNSTER V J.Animal models of disease shed light on Nipah virus pathogenesis and transmission[J].J Pathol, 2015, 235(2):196-205
[26]MIRE C E, CHAN Y P, BORISEVICH V, et al.A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection[J].J Infect Dis, 2020, 221(Suppl 4):S471-S9
[27]MIDDLETON D J, WESTBURY H A, MORRISSY C J, et al.Experimental Nipah virus infection in pigs and cats[J].J Comp Pathol, 2002, 126(2-3):124-36
[28]CHUA K B.Nipah virus outbreak in Malaysia[J].J Clin Virol, 2003, 26(3):265-75
[29]BERHANE Y, WEINGARTL H M, LOPEZ J, et al.Bacterial infections in pigs experimentally infected with Nipah virus[J].Transbound Emerg Dis, 2008, 55(3-4):165-74
[30]GEISBERT T W, DADDARIO-DICAPRIO K M, HICKEY A C, et al.Development of an acute and highly pathogenic nonhuman primate model of Nipah virus infection[J].PLoS One, 2010, 5(5):e10690-e10690
[31]DHONDT K P, HORVAT B.Henipavirus infections: lessons from animal models[J].Pathogens, 2013, 2(2):264-87
[32]GEISBERT T W, FELDMANN H, BRODER C C.Animal challenge models of henipavirus infection and pathogenesis.[J].Curr Top Microbiol Immunol, 2012, 359:153-77
[33]WOOLSEY C, BORISEVICH V, FEARS A C, et al.Recombinant vesicular stomatitis virus-vectored vaccine induces long-lasting immunity against Nipah virus disease.[J].J Clin Invest, 2023, 133(3):e164946-e164946
[34]MAISNER A, NEUFELD J, WEINGARTL H.Organ- and endotheliotropism of Nipah virus infections in vivo and in vitro[J].Thromb Haemost, 2009, 102(6):1014-23
[35]WEINGARTL H M, BERHANE Y, CZUB M.Animal models of henipavirus infection: a review[J].Vet J, 2009, 181(3):211-20
[36]PIGEAUD D D, GEISBERT T W, WOOLSEY C.Animal Models for Henipavirus Research [J].[J].Viruses, 2023, 15(10):1980-1980
[37]MIDDLETON D J, MORRISSY C J, VAN DER HEIDE B M, et al.Experimental Nipah virus infection in pteropid bats (Pteropus poliocephalus)[J].J Comp Pathol, 2007, 136(4):266-72
[38]TORRES-VELEZ F J, SHIEH W J, ROLLIN P E, et al.Histopathologic and immunohistochemical characterization of Nipah virus infection in the guinea pig[J].Vet Pathol, 2008, 45(4):576-85
[39]DHONDT K P, MATHIEU C, CHALONS M, et al.Type I interferon signaling protects mice from lethal henipavirus infection[J].J Infect Dis, 2013, 207(1):142-51
[40]IAMPIETRO M, AURINE N, DHONDT K P, et al.Control of Nipah Virus Infection in Mice by the Host Adaptors Mitochondrial Antiviral Signaling Protein (MAVS) and Myeloid Differentiation Primary Response 88 (MyD88)[J].J Infect Dis, 2020, 221(Suppl 4):S401-S6
[41]IAMPIETRO M, DUMONT C, MATHIEU C, et al.Activation of cGASSTING pathway upon paramyxovirus infection[J].iScience, 2021, 24(6):102519-102519
[42]王晴, 聂建辉, 梁春南.尼帕假病毒感染金黄地鼠模型的建立[J].中国病原生物学杂志, 2020, 15(11):1272-6
[43]王晴.基于假病毒的尼帕病毒（NiV）流行株抗原性及动物模型的研究 [D]; 中国食品药品检定研究院, 2020.
[44]GAO Z, LI T, HAN J, et al.Assessment of the immunogenicity and protection of a Nipah virus soluble G vaccine candidate in mice and pigs [J].[J].Front Microbiol, 2022, 13:1031523-1031523
[45]BOSSART K N, ZHU Z, MIDDLETON D, et al.A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection[J].PLoS Pathogens, 2009, 5(10):e1000642-e1000642