Objective To propose a set of referable and replicable standardized management system of sensory control technology, so as to provide reference for promoting the rational application of antibiotics in hospitals and curbing bacterial drug resistance. Methods With the establishment of a microbiological monitoring management system and rational application management system of antibiotics as the starting point and the cultivation of professional talents as the carrier, the management strategy based on the linkage of hospital sense, medical, clinical, pharmaceutical, laboratory and nursing departments was formed and continuously optimized. The detection situations of multi-drug resistant bacteria, occurrence of nosocomial infection, relevant indicators of rational use of antibiotics in our hospital from January 2018 to December 2022 were retrospectively analyzed to evaluate the implementation effect of this strategy. Results In the process of constructing and gradually improving the multi-department linkage management strategy, the pre-application detection rate of inpatient antibiotics increased from 61.32% to 64.17% from 2019-2022 compared with 2017-2019, and the infection rate of multi-drug resistant bacteria MRSA, CRKPN, CRAB and CRPA in hospitals showed a significant decline. The intensity of antibiotic use during hospitalization decreased from 43.32 (2018) to 40.39 (2022). Conclusion The multi-department linkage management system based on precision infection control proposed in this study can effectively promote the rational application of antibiotics and curb bacterial drug resistance, and this system can be used as a reference for hospital infection control departments to promote and replicate in medical institutions.