Elizabethkingia meningoseptica (EM) can cause meningitis, sepsis, lung infection, eye infection, catheter-related bloodstream infection and surgical site infection. EM is one of the important pathogens of nosocomial infection. The infection mechanisms of EM include invasion of host cells，production of proteases，biofilms，etc，and EM can produce related virulence factors to damage the immune system. In addition，EM carries multiple drug resistance genes and is resistant to commonly used antibiotics in clinical practice. This article reviews the infection types，clinical features and infection mechanisms of EM, which would provide a reference for the diagnosis and clinical treatment of EM infection.