Analysis of pathogen distribution and drug sensitivity of bloodstream infection in Traditional Chinese Medicine

ZHANG Mei-Yun; LIU Rui-Jie; ZHANG Shao-Xin; XUN Gui-Qin

doi:10.3969/j.issn.1673-6184.2024.06.003

Journal of Microbes and Infections ›› 2024, Vol. 19 ›› Issue (6) : 343-350. DOI: 10.3969/j.issn.1673-6184.2024.06.003

Original Article

Analysis of pathogen distribution and drug sensitivity of bloodstream infection in Traditional Chinese Medicine

ZHANG Meiyun¹, LIU Ruijie², ZHANG Shaoxin², SUN Guiqin²

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Abstract

This study aimed to analyze the distribution and drug sensitivity of pathogenic bacteria of bloodstream infections in patients hospitalized in Xinchang County Hospital of Traditional Chinese Medicine, providing a basis for the diagnosis and treatment of clinical bloodstream infections. All blood culture samples from Xinchang County Hospital of Traditional Chinese Medicine were collected from January 2019 to June 2023, and the pathogen species and drug sensitivity in vitro were analyzed statistically. A total of 1692 positive blood culture samples were obtained, primarily from the intensive care unit (ICU). The pathogens detected included 1637 aerobic (96.74%), 19 anaerobic (1.12%) and 36 fungal (2.13%) strains. The gram-negative bacteria (36.63%) were mainly Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis, and the gram-positive bacteria (63.12%) were mainly Staphylococcus hominis, Staphylococcus epidermidis, and Staphylococcus aureus. Drug sensitivity results indicated that Escherichia coli and Klebsiella pneumoniae exhibited resistance rates exceeding 70% to aztreonam but sensitivity rates exceeding 70% to cephalosporins. In contrast, Staphylococcus epidermidis, Staphylococcus aureus and Staphylococcus hominis showed resistance rates exceeding 70% to penicillin, but high sensitivity (greater than 90%) to antimicrobial agents such as linezolid and tigecycline. The positive blood culture samples are predominantly from wards housing immunocompromised patients. The primary pathogenic bacteria identified were Escherichia coli, Klebsiella pneumoniae, Staphylococcus hominis and Staphylococcus epidermidis, which are sensitive to some antibacterial drugs. However, the widespread use of antibiotics in treatment may lead to changes in drug resistance patterns. Therefore, clinical practices should emphasize the detection of pathogenic bacteria and their drug susceptibility profiles to guide the diagnosis and treatment of bloodstream infections.

Key words

Hospital of Traditional Chinese Medicine / Bloodstream infection / Pathogenic bacteria / Drug susceptibility test

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ZHANG Meiyun1, LIU Ruijie2, ZHANG Shaoxin2, SUN Guiqin2. Analysis of pathogen distribution and drug sensitivity of bloodstream infection in Traditional Chinese Medicine[J]. Journal of Microbes and Infections. 2024, 19(6): 343-350 https://doi.org/10.3969/j.issn.1673-6184.2024.06.003