Objective To discuss the serotype distribution and drug resistance of nontyphoidal salmonellosis (NTS) infection in children in Tangshan City from 2022 to 2024. Methods: From January 2022 to December 2024, 235 children diagnosed with NTS infection in our hospital were served as subjects. The basic characteristics of the children were statistically explored, and the cultured NTS were subjected to serotype and drug sensitivity tests to analyze the drug resistance of NTS detected in different years. Results In 2022, 2023, and 2024, 79, 84, and 72 cases of NTS infection were detected in the Tangshan area, respectively, with no conspicuous difference in the proportions of male and female cases (P>0.05). Among 235 children with NTS infection, those < 1 year old accounted for the highest proportion (45.53%), while those aged 1-2 years (excluding 2 years) accounted for 29.79%. From 2022 to 2024, the NTS infection rate among children in the Tangshan area was highest in summer and lowest in winter. The serotype test showed that a total of 17 serotypes were detected in 235 children with NTS infection, of which 51.91% were Salmonella typhimurium and 15.32% were Salmonella enteritis. The drug sensitivity test revealed that 235 NTS strains had the highest resistance rate to ampicillin (average value was 77.02%), a relatively high resistance rate to compound sulfamethoxazole (average value was 48.09%), and a relatively low resistance rate to antibiotics such as ceftriaxone (average value was 16.60%) and ceftazidime (average value was 22.55%). There was no conspicuous difference (P>0.05) in the resistance rates of Salmonella typhimurium and Salmonella enteritis to eight antibiotics, including ampicillin. Conclusion: The serotypes of NTS infected children in Tangshan city are mainly Salmonella typhimurium and Salmonella enteritis. NTS strains have a high resistance rate to ampicillin and compound sulfamethoxazole. In clinical practice, antibiotics should be selected reasonably based on the serotype and resistance of NTS infected children to avoid overuse of antibiotics.
Key words
Nontyphoidal salmonellosis infection /
Children /
Serotypes /
Drug resistance
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References
[1] Bj?rklund L, Mattisson Y, Bl?ckberg A, et al. A Population-Based Study on the Incidence, Risk Factors, and Outcome of Salmonella Bloodstream Infections in South Sweden 2012-2022[J]. Infect Dis Ther, 2024, 13(3):501-519.
[2] Quach A, Jayaratne R R, Lee B J, et al. Diarrhoeal pathogenesis in Salmonella infection may result from an imbalance in intestinal epithelial differentiation through reduced Notch signalling[J]. J Physiol, 2022, 600(8):1851-1865.
[3] 邹敏, 何冬梅, 徐静, 等. 广东省2018-2022年侵袭性非伤寒沙门菌病原学特征分析[J].中华流行病学杂志, 2024, 45(4):520-528.
[4] Sheen J M, Lin F J, Yang Y H, et al. Increased non-typhoidal Salmonella hospitalizations in transfusion-na?ve thalassemia children: a nationwide population-based cohort study[J]. Pediatr Res, 2022, 91(7):1858-1863.
[5] Marchello C S, Birkhold M, Crump J A, et al. Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis[J]. Lancet Infect Dis, 2022, 22(5):692-705.
[6] Rosso F, Rebellón-Sánchez DE, Llanos-Torres J, et al. Clinical and microbiological characterization of Salmonella spp. isolates from patients treated in a university hospital in South America between 2012-2021: a cohort study[J]. BMC Infect Dis, 2023, 23(1):625-636.
[7] Kavai S M, Mbae C, Wairimu C, et al. Association of Sickle Cell Disease, Malaria and HIV in Multi Drug Resistant Invasive Non-typhoidal?Salmonella?Isolated from Outpatient and Hospitalised Children Below 16 Years in Informal Settlements in Nairobi County, Kenya[J]. East Afr Sci, 2024, 6(1):48-54.
[8] Clinical and Laboratory Standards Institute. M100 Performance standards for antimicrobial susceptibility testing [S]. Wayne, PA:CLSI, 2019: 17-38.
[9] Jacob J J, Solaimalai D, Rachel T, et al. A secular trend in invasive non-typhoidal Salmonella in South India, 2000-2020: Identification challenges and antibiogram[J]. Indian J Med Microbiol, 2022, 40(4):536-540.
[10] 郭帅, 万朝敏. 儿童非伤寒沙门菌败血症13例病例系列报告[J]. 中国循证儿科杂志, 2023, 18(2):129-132.
[11] Amir Y, Omar M, Adler A, et al. The prevalence of antimicrobial drug resistance of non-typhoidal Salmonella in human infections in sub-Saharan Africa: a systematic review and meta-analysis[J]. Expert Rev Anti Infect Ther, 2024, 22(9):761-774.
[12] Sachu A. Prevalence and antimicrobial susceptibility pattern of?Salmonella?and?Shigella?in stool among patients presenting with diarrhea in a tertiary care centre in South India[J]. Iran J Microbiol, 2023, 15(2):236-242.
[13]傅芬蕊, 马莉莉, 钟文. 2017～2020年我院非伤寒沙门菌感染患儿流行病学特点及药敏分析[J]. 药物流行病学杂志, 2021, 30(11):735-738.
[14] Chen H, Qiu H, Zhong H, et al. Non-Typhoidal?Salmonella?Infections Among Children in Fuzhou, Fujian, China: A 10-Year Retrospective Review from 2012 to 2021[J]. Infect Drug Resist, 2023, 16(1):2737-2749.
[15] Gong B, Feng Y, Zhuo Z, et al. Epidemiological, Genetic, and Phenotypic Characteristics of Non-Typhoidal?Salmonella?in Young Children, as Obtained from a Tertiary Hospital in Guangzhou, China[J]. Microorganisms, 2023, 11(10):2433-2445.
[16] John P, Varga C, Cooke M, et al. Incidence, Demographic, and Seasonal Risk Factors of Infections Caused by Five Major Enteric Pathogens, Ontario, Canada, 2010-2017[J]. Foodborne Pathog Dis, 2022, 19(4):248-258.
[17] 沈银芳, 许学斌, 龚敬宇, 等. 2018—2021年上海市金山医院儿童非伤寒沙门菌感染的临床流行特征和药敏分析[J]. 微生物与感染, 2023, 18(2):75-82.
[18] 李迟. 2016-2022年安徽省某医院儿童非伤寒沙门氏菌感染的流行病学特征及耐药性分析[D]. 合肥: 安徽医科大学, 2023.
[19] 陈相好, 杨光武, 田仁贵, 等. 2020-2022年贵州省遵义市非伤寒沙门菌感染流行特征及耐药性研究[J]. 疾病监测, 2024, 39(11):1438-1442.
