The mechanism of action of fucoidan in antagonizing Helicobacter pylori infection and regulating gut microbiota

Journal of Microbes and Infections ›› 2025, Vol. 20 ›› Issue (3) : 182-192.

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Journal of Microbes and Infections ›› 2025, Vol. 20 ›› Issue (3) : 182-192.

The mechanism of action of fucoidan in antagonizing Helicobacter pylori infection and regulating gut microbiota

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Abstract

Helicobacter pylori (Hp), as a common gastric pathogen, has a high global infection rate and is the main cause of various gastrointestinal diseases such as gastritis, gastric ulcers, and gastric cancer. The treatment of eradicating Hp infection NOt only improves the diseases related to gastric inflammation and intestinal microbiota disorders caused by it, but also reduces the risk of gastric cancer. However, with the widespread use of antibiotics, the resistance of Hp continues to rise, increasing the failure rate of treatment. Therefore, there is an urgent need to find new treatment options or adjuvant drugs. Fucoidan has attracted much attention due to its unique biological functions and wide application fields. Research has found that Fucoidan has therapeutic and preventive effects on Hp infection related gastritis and intestinal microbiota disorders. This article elaborates on the main role and related mechanisms of Fucoidan in antagonizing Hp infection, including direct inhibition, reduction of inflammatory response, enhancement of antioxidant capacity, and regulation of gut microbiota. It provides a theoretical basis for Fucoidan to become an effective drug for treating Hp infection and aims to incorporate it into the treatment plan for eradicating Hp infection.

Key words

Fucoidan / Helicobacter pylori / Chinese herbal polysaccharides / Gut microbiota / prebiotics

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The mechanism of action of fucoidan in antagonizing Helicobacter pylori infection and regulating gut microbiota[J]. Journal of Microbes and Infections. 2025, 20(3): 182-192

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[1]Yi M ,Chen S ,Yi X , et al.Helicobacter pylori infection process: from the molecular world to clinical treatment[J].Frontiers in Microbiology,2025,161541140-1541140. [2]Duan Y ,Xu Y ,Dou Y , et al.Helicobacter pylori and gastric cancer: mechanisms and new perspectives[J].Journal of Hematology & Oncology,2025,18(1):10-10. [3]Chengyao W ,Wenkun L ,Linlin S , et al.Both extracellular vesicles from helicobacter pylori-infected cells and helicobacter pylori outer membrane vesicles are involved in gastric/extragastric diseases[J].European Journal of Medical Research,2023,28(1):484-484. [4]Chey D W ,Howden W C ,Moss F S , et al.ACG Clinical Guideline: Treatment of Helicobacter pylori Infection.[J].The American journal of gastroenterology,2024,119(9):1730-1753. [5]Shadvar N ,Akrami S ,Sagharchi M A M S , et al.A review for non-antibiotic treatment of Helicobacter pylori: new insight[J].Frontiers in Microbiology,2024,151379209-1379209. [6]Zhao Y ,Ning L ,Zhu P , et al.The Origin, Properties, Structure, Catalytic Mechanism, and Applications of Fucoidan-Degrading Enzymes[J].Marine Drugs,2025,23(3):97-97. [7]Ren X ,Cai S ,Zhong Y , et al.Marine-Derived Fucose-Containing Carbohydrates: Review of Sources, Structure, and Beneficial Effects on Gastrointestinal Health[J].Foods,2024,13(21):3460-3460. [8]Chen BR, Li WM, Li TL, Chan YL, Wu CJ. Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori[J]. Sci Rep. 2022;12(1):429. Published 2022 Jan 10. [9]Silvia S ,Irene M ,Federica L , et al.Helicobacter pylori and Gastric Cancer: Pathogenetic Mechanisms[J].International Journal of Molecular Sciences,2023,24(3):2895-2895. [10]Elshenawi Y ,Hu S ,Hathroubi S .Biofilm ofHelicobacter pylori : Life Cycle, Features, and Treatment Options[J].Antibiotics,2023,12(8): [11]Ong L L , Lin C H. Adhesion, infection, and therapeutic treatment of Helicobacter pylori: a review on current aspects and future promise[J]. Discov Appl Sci 6, 323 (2024). [12]Hang Y ,Lixia W ,Miao Z , et al.The Role of Adhesion in Helicobacter pylori Persistent Colonization.[J].Current microbiology,2023,80(5):185-185. [13]Barhoine M ,Moustaoui F ,Hammani O , et al.The Effect of Helicobacter pylori Gene Combinations of cagA, cagE, virB11, vacA, and babA on the Outcome of Gastric Disease in a Southern Moroccan Population[J].Pathogens,2025,14(3):279-279. [14]Cao J ,Qin L ,Liu M , et al.Fucoidan from sea cucumber cooking liquid: Structural analysis, physicochemical properties, and anti-Helicobacter pylori potential.[J].International journal of biological macromolecules,2025,141593. [15]Eng-Guan C ,Phebe V ,T T P , et al.Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro.[J].Evidence-based complementary and alternative medicine : eCAM,2015,2015120981. [16]孙静,邹圆静,孙璇,等. 葡萄籽提取物和岩藻多糖组合物抗幽门螺杆菌作用及机制研究[ J] . 食品与发酵工业,2024,50(18) :279 - 283. [17]Rita M ,Irina A ,Ana M , et al.Adhesion of Helicobacter Species to the Human Gastric Mucosa: A Deep Look Into Glycans Role[J].Frontiers in Molecular Biosciences,2021,8656439-656439. [18]Roy A, Roy PK, Cho SR, Park SY. Effects of Fucoidan on the Inhibition of Biofilm Formation of Salmonella enterica Subsp. enterica Serovar Typhimurium on Seafoods and Its Molecular Antibiofilm Mechanisms. Microorganisms. 2025; 13(4):914. [19]Fauzia A K ,Effendi I W ,Alfaray I R , et al.Molecular Mechanisms of Biofilm Formation in Helicobacter pylori[J].Antibiotics,2024,13(10):976-976. [20]Zhang S ,Ma S ,Hao S , et al.Fucoidan-modified antibiotic-free nanovesicles: A multidimensional approach to eradicate intracellular and extracellular Helicobacter pylori and restore gastrointestinal homeostasis.[J].International journal of biological macromolecules,2025,307(P2):141786. [21]Shu C ,Zhang W ,Zhang Y , et al.Copper-Bearing Metal-Organic Framework with Mucus-Penetrating Function for the Multi-Effective Clearance of Mucosal Colonized Helicobacter pylori.[J].Research (Washington, D.C.),2024,70358-0358. [22]Asanka K K S ,M. N I H K H ,HyeWon Y , et al.Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review[J].Marine Drugs,2021,19(12):678-678. [23]M N L ,HyoGeun L ,P D N , et al.Fucoidan from Sargassum autumnale Inhibits Potential Inflammatory Responses via NF-κB and MAPK Pathway Suppression in Lipopolysaccharide-Induced RAW 264.7 Macrophages.[J].Marine drugs,2023,21(7): [24]Hou T ,Liu X ,Zhang S , et al.Anti-inflammatory Effects of the Fucoidan from Sea Cucumber Apostichopus japonicus.[J].Marine biotechnology (New York, N.Y.),2025,27(1):32. [25]Wang L ,Oh J ,Yang H , et al.Fucoidan isolated from the popular edible brown seaweed Sargassum fusiforme suppresses lipopolysaccharide-induced inflammation by blocking NF-κB signal pathway[J].Journal of Applied Phycology,2021,33(3):1-8. [26]Rui L ,QingLing Z ,ShuTong C , et al.Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum[J].Marine Drugs,2022,21(1):18-18. [27]Pozharitskaya N O ,Obluchinskaya D E ,Shikov N A .Mechanisms of Bioactivities of Fucoidan from the Brown Seaweed Fucus vesiculosus L. of the Barents Sea[J].Marine Drugs,2020,18(5):275-275. [28]Ni L ,Wang L ,Fu X , et al.In vitro and in vivo anti-inflammatory activities of a fucose-rich fucoidan isolated from Saccharina japonica[J].International Journal of Biological Macromolecules,2020,156(prepublish):717-729. [29]Acevedo S ,Covarrubias A A ,Haeger P , et al.Alginate Oligosaccharides Protect Gastric Epithelial Cells against Oxidative Stress Damage through Induction of the Nrf2 Pathway[J].Antioxidants,2024,13(5):618-. [30]Deghrigue M ,Cherif D ,Lajili S , et al.Structural characterizations and bioactivities of fucoidans from Dyctyopteris membranaceae and Padina pavonica with in silico investigations.[J].International journal of biological macromolecules,2025,307(P3):142133. [31]Lilong W ,Linlin W ,Chunhong Y , et al.Structural characterization of a fucoidan from Ascophyllum nodosum and comparison of its protective effect against cellular oxidative stress with its analogues.[J].International journal of biological macromolecules,2023,239124295-124295. [32]Lukova P ,Apostolova E ,Baldzhieva A , et al.Fucoidan fromEricaria crinitaAlleviates Inflammation in Rat Paw Edema, Downregulates Pro-Inflammatory Cytokine Levels, and Shows Antioxidant Activity[J].Biomedicines,2023,11(9): [33]Fan S ,Xu Y ,Wang L , et al.Sargassum hornery fucoidan oligosaccharide: Purification, characterization, and antioxidant effects targeting the MAPK and KEAP1-NRF2 signaling pathways[J].Algal Research,2024,84103756-103756. [34]Suzuki H ,Hirai M .Helicobacter pylori infection and oxidative stress.[J].Journal of clinical biochemistry and nutrition,2024,75(3):178-182. [35]Lei W ,Ri Y C ,HyoGeon L , et al.Fucoidan isolated from fermented Sargassum fusiforme suppresses oxidative stress through stimulating the expression of superoxidase dismutase and catalase by regulating Nrf2 signaling pathway.[J].International journal of biological macromolecules,2022,209(PA):935-941. [36]Lei W ,Ri Y C ,Kaiqiang W , et al.Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.[J].International journal of biological macromolecules,2022,222(PB):2065-2071. [37]Yueqi K ,Lei W ,Jin Y J , et al.In vitro and in vivo antioxidant activities of a fucose-rich fucoidan isolated from Saccharina japonica[J].Journal of Applied Phycology,2022,35(1):353-364. [38]Cao C ,Yue S ,Lu A , et al.Host-Gut Microbiota Metabolic Interactions and Their Role in Precision Diagnosis and Treatment of Gastrointestinal Cancers.[J].Pharmacological research,2024,207107321. [39]Marcello F ,Ege T ,Enrico L V D , et al.The Influence of Helicobacter pylori on Human Gastric and Gut Microbiota.[J].Antibiotics (Basel, Switzerland),2023,12(4):765-. [40]Aijun C ,Yatong L ,Tao Z , et al.Chain conformation, mucoadhesive properties of fucoidan in the gastrointestinal tract and its effects on the gut microbiota[J].Carbohydrate Polymers,2023,304120460-120460. [41]Huang X ,Nie S ,Fu X , et al.Exploring the prebiotic potential of hydrolyzed fucoidan fermented in vitro with human fecal inocula: Impact on microbiota and metabolome.[J].International journal of biological macromolecules,2024,267(P1):131202-131202. [42]Tohumcu E ,Kaitsas F ,Bricca L , et al.Helicobacter pylori and the Human Gastrointestinal Microbiota: A Multifaceted Relationship[J].Antibiotics,2024,13(7):584-584. [43]Engelsberger V ,Gerhard M ,Luque M R .Effects of Helicobacter pylori infection on intestinal microbiota, immunity and colorectal cancer risk.[J].Frontiers in cellular and infection microbiology,2024,141339750-1339750. [44]Shu W ,Zibin T ,Jianwei C , et al.Effect of fucoidan on gut microbiota and its clinical efficacy in Helicobacter pylori eradication: a randomised controlled trial.[J].Journal of digestive diseases,2023,24(8-9):461-471. [45]Zhou X ,Zhang Y ,Wei L , et al.In vitro fermentation characteristics of fucoidan and its regulatory effects on human gut microbiota and metabolites[J].Food Chemistry,2025,465(P1):141998-141998. [46]Wang H ,Wei W ,Liu F , et al.Effects of fucoidan and synbiotics supplementation during bismuth quadruple therapy of Helicobacter pylori infection on gut microbial homeostasis: an open-label, randomized clinical trial[J].Frontiers in Nutrition,2024,111407736-1407736. [47]张雪琳,蒋晨,徐珊,等.岩藻多糖对幽门螺杆菌感染后小鼠肠道菌群紊乱的调节作用[J].精准医学杂志,2021,36(03):222-226+230.DOI:10.13362/j.jpmed.202103008. [48]Wu M ,Tian C ,Zou Z , et al.Gastrointestinal Microbiota in Gastric Cancer: Potential Mechanisms and Clinical Applications—A Literature Review[J].Cancers,2024,16(20):3547-3547. [49]Xiaoxia L ,Yunhui Z ,Wanhua L , et al.Fucoidan Ameliorated Dextran Sulfate Sodium-Induced Ulcerative Colitis by Modulating Gut Microbiota and Bile Acid Metabolism.[J].Journal of agricultural and food chemistry,2022, [50]He Y, Shaoyong W, Chen Y,et al. The functions of gut microbiota-mediated bile acid metabolism in intestinal immunity. J Adv Res. 2025 May 10:S2090-1232(25)00307-8. [51]Ying Y ,Meina L ,Dan O , et al.Research Progress on the Protective Effect of Brown Algae-Derived Polysaccharides on Metabolic Diseases and Intestinal Barrier Injury[J].International Journal of Molecular Sciences,2022,23(18):10784-10784. [52]Fu X ,Huang X ,Tan H , et al.Regulatory Effect of Fucoidan Hydrolysates on Lipopolysaccharide-Induced Inflammation and Intestinal Barrier Dysfunction in Caco-2 and RAW264.7 Cells Co-Cultures[J].Foods,2024,13(22):3532-3532. [53]Qin W ,Wei B ,Ren P , et al.Fucoidan from Apostichopus japonicus enhances intestinal barrier function and promotes intestinal immunity via regulating the gut microbiota and tryptophan metabolism.[J].International journal of biological macromolecules,2025,301139929. [54]Yang L ,Qing L ,Chengcheng Z , et al.Strain-specific effects of Akkermansia muciniphila on the regulation of intestinal barrier[J].Food Science and Human Wellness,2023,12(5):1526-1537.

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