Sepsis is a systemic inflammatory response syndrome caused by bacterial, viral and fungal infections. This inflammatory response induced by pathogenic microorganisms can lead to the failure of multiple organ systems, resulting in serious consequences. Studies have shown that the expression of some non-coding RNAs such as long noncoding RNA (lncRNA), microRNA (miRNA) and circular RNA (circRNA) changes during sepsis. These transcripts can participate in multiple organ system failure through different mechanisms. Correct understanding of the role of non-coding RNA in the pathogenesis of sepsis is of great significance for the early detection, diagnosis and treatment of sepsis in clinical practice. This review mainly describe the role of these three classes of non-coding RNAs in sepsis and its related complications.