A total of 82 strains of Klebsiella pneumoniae (KPN) clinically isolated from East Hospital Affiliated to Tongji University in Shanghai from October to December 2022 were collected in this study. Real-time fluorescent polymerase chain reaction (PCR)and enzyme inhibitor enhanced test were used to detect carbapenemase-producing genotypes of the strains. Simultaneously, the minimum inhibitory concentration (MIC) and inhibitory zone diameter of ceftazidime-avibactam (CZA) against these strains of Klebsiella pneumoniae were detected by microbroth dilution method and Kirby-Bauer disk diffusion method, respectively, to verify whether disk diffusion method could serve as a reliable alternative to the microbroth dilution method for CZA susceptibility testing. The results demonstrated complete concordance between carbapenemase genotypes (real-time PCR) and phenotypes (enzyme inhibitor enhancement test). Comparative analysis of the two susceptibility testing methods revealed high agreement between disk diffusion and microbroth dilution. The results of the two disk diffusion methods and the micro-broth dilution method revealed high agreement with categorical agreement (CA) rates of 98.3% and 99.7% and no major errors (ME ＝ 0). This study confirmed that the disk diffusion method can be used to detect the drug susceptibility of CZA to KPN. However, it still needs to be checked by broth dilution method if the inhibition zone range is within 20-22 mm.