Tuberculosis is a global health concern. Cell-mediated immunity plays important roles against the infection. Several types of immune cells and cytokines play key roles in the pathogenesis, development and prognosis of tuberculosis through a variety of mechanisms. Neutrophils participate in constituting the first line of defense to Mycobacterium tuberculosis (M. tuberculosis). Neutrophils gather at the infection site rapidly after infection, and play the roles of anti-tuberculosis immunity through various mechanisms, such as phagocytosis, apoptosis, granuloma formation, neutrophil extracellular traps and producing effector cytokines. In addition, neutrophils also participate in the tissue injury process in tuberculosis patients. The recent research progress on the functions of neutrophils and some cytokines related to the immune response to tuberculosis is summarized.