Microbial communities with complex structure are colonized in human body, hosting interactions between fungi and bacteria. Early studies have focused mainly on a single species of bacteria or fungi, and recent studies have shown the interactions between bacteria and fungi are critical to study human microecosystems. Candida albicans is the most common opportunistic pathogenic fungus for human and is generally considered to be part of the normal human flora. The interactions between Candida albicans and bacteria, especially their synergistic and antagonistic effects on the balance between different species, have attracted more attentions in recent years. This paper reviews the mechanism of interactions between Candida albicans and bacteria and their impacts on human diseases.